Tom L Blundell Selected Research

Enzymes

1/2021	Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis.
1/2020	Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
11/2019	Mycobacterial OtsA Structures Unveil Substrate Preference Mechanism and Allosteric Regulation by 2-Oxoglutarate and 2-Phosphoglycerate.
1/2016	Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on 'black bone disease' in Italy.
1/2015	Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis.
6/2011	Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.
11/2002	Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.

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Tom L Blundell Research Topics

Disease

23	Neoplasms (Cancer) 11/2023 - 06/2003
21	Tuberculosis (Tuberculoses) 04/2023 - 06/2011
8	Infections 01/2022 - 01/2017
4	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 01/2016
4	Communicable Diseases (Infectious Diseases) 01/2020 - 01/2014
3	Alzheimer Disease (Alzheimer's Disease) 08/2020 - 12/2018
3	Leprosy (Hansen's Disease) 01/2020 - 01/2018
3	Acquired Immunodeficiency Syndrome (AIDS) 01/2017 - 06/2005
3	Breast Neoplasms (Breast Cancer) 09/2003 - 11/2002
2	Cystic Fibrosis (Mucoviscidosis) 10/2022 - 01/2019
2	COVID-19 01/2022 - 01/2021
2	Dissociative Disorders (Fugue) 01/2020 - 01/2004
2	Genomic Instability 12/2018 - 03/2004
1	Myalgia 01/2022
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2021
1	Carcinogenesis 10/2020
1	Proteostasis Deficiencies 10/2020
1	Immune System Diseases (Immune Disorders) 01/2020
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2019
1	Amyloidosis 12/2018
1	Rupture 01/2018
1	Alkaptonuria 01/2016
1	Neoplasm Metastasis (Metastasis) 01/2016
1	Starvation 12/2015
1	Hypoxia (Hypoxemia) 11/2014
1	Toxoplasmosis 11/2014
1	Renal Cell Carcinoma (Grawitz Tumor) 08/2012
1	Paraganglioma (Paragangliomas) 01/2010

Drug/Important Bio-Agent (IBA)

24	Proteins (Proteins, Gene)FDA Link 01/2022 - 11/2002
9	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 03/2004
7	EnzymesIBA 01/2021 - 11/2002
3	Coenzyme A (CoA)IBA 04/2023 - 11/2021
3	Oxidoreductases (Dehydrogenase)IBA 10/2022 - 01/2004
3	DNA-Activated Protein KinaseIBA 01/2022 - 03/2004
3	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2022 - 01/2018
3	LigandsIBA 11/2021 - 01/2016
3	Peptides (Polypeptides)IBA 08/2020 - 12/2018
3	Amyloid (Amyloid Fibrils)IBA 08/2020 - 12/2018
3	Antiviral Agents (Antivirals)IBA 01/2017 - 06/2005
2	RNA (Ribonucleic Acid)IBA 01/2022 - 11/2021
2	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2022 - 01/2017
2	ProdrugsIBA 01/2021 - 01/2017
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 08/2020 - 07/2019
2	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 01/2020 - 01/2014
2	Rifampin (Rifampicin)FDA LinkGeneric 01/2020 - 01/2018
2	Peptide Hydrolases (Proteases)FDA Link 07/2019 - 11/2005
2	Protein Subunits (Protein Subunit)IBA 01/2019 - 11/2015
2	GuanineIBA 01/2017 - 01/2017
2	HIV ProteaseIBA 01/2017 - 01/2016
2	shikimateIBA 01/2015 - 06/2011
1	MutagensIBA 11/2023
1	Uridine Diphosphate (UDP)IBA 10/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	DNA VaccinesIBA 01/2022
1	SARS-CoV-2 spike proteinIBA 01/2021
1	Heme (Haem)IBA 01/2021
1	Isoniazid (Ftivazide)FDA LinkGeneric 01/2021
1	IntegrinsIBA 01/2021
1	A-Form DNA (A-DNA)IBA 11/2020
1	Long Noncoding RNAIBA 11/2020
1	pleiotrophin (HARP)IBA 01/2020
1	Nucleic AcidsIBA 01/2020
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2020
1	Folic Acid AntagonistsIBA 01/2020
1	1-(5-isoquinolinesulfonyl)piperazineIBA 07/2019
1	PresenilinsIBA 07/2019
1	Flavin-Adenine Dinucleotide (FAD)IBA 07/2019
1	Complement System Proteins (Complement)IBA 01/2019
1	Type 6 Cyclic Nucleotide PhosphodiesterasesIBA 01/2019
1	Neurotransmitter Agents (Neurotransmitter)IBA 12/2018
1	AcetylcholinesteraseIBA 12/2018
1	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2018
1	Arginine (L-Arginine)FDA Link 01/2018
1	Ethionamide (Trecator-SC)FDA Link 01/2017
1	ZincIBA 01/2017
1	Hemoglobins (Hemoglobin)IBA 01/2017
1	ReninIBA 01/2017
1	Inosine Monophosphate (IMP)IBA 01/2017
1	Insulin (Novolin)FDA Link 01/2017
1	venetoclaxIBA 01/2017
1	Antihypertensive Agents (Antihypertensives)IBA 01/2017
1	VemurafenibIBA 01/2017
1	InsulinsIBA 01/2017
1	Thymidylate SynthaseIBA 10/2016
1	pantothenate synthetaseIBA 01/2016
1	Proto-Oncogene Proteins c-metIBA 01/2016
1	Phosphotransferases (Kinase)IBA 01/2016
1	AntibodiesIBA 01/2016
1	CarbonIBA 12/2015
1	ProteomeIBA 01/2015
1	PlatinumIBA 01/2015
1	ElonginIBA 11/2014
1	Pyrimethamine (Daraprim)FDA Link 11/2014
1	5,6,7,8-tetrahydrofolic acid (tetrahydrofolate)IBA 01/2014
1	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 08/2012
1	Succinate Dehydrogenase (Fumarate Reductase)IBA 01/2010

Therapy/Procedure

7	Therapeutics 01/2021 - 01/2016
1	Radiotherapy 01/2022
1	Drug Therapy (Chemotherapy) 01/2021
1	Transplantation 01/2019